Some people make power immune system proteins after they are infected with the disease, which can help them to survive for longer.
Scientists said they hoped to develop a vaccine that could trigger anyone's body to produce these 'super' antibodies.
Antibodies that are ineffective or disable just a couple of HIV strains are common. Until last year only a handful were found to neutralize a large number of strains and none of them worked in more than 40 per cent of cases.
Now researchers have revealed three powerful antibodies have been discovered. Writing in the journal Science today, they said that one of them neutralised 91 per cent of HIV strains.
Study author Dr Gary Nabel of the National Institute of Allergy and Infectious Diseases,said: 'This is an antibody that evolved after the fact. That is part of the problem we have in dealing with HIV - once a person becomes infected, the virus always gets ahead of the immune system.
'What we are trying to do with a vaccine is get ahead of the virus.'
In the UK, there are 73,000 people living with HIV - the virus that progresses into AIDS - and experts believe that 30 per cent of people with HIV do not know they have the condition.
Footballer Didier Drogba and musician Bono are just two of the celebrities involved in raising money to fight HIV/AIDS in Africa. It infects around 33m around the globe.
Globally AIDS infects about 33 million people and has killed 25 million people since the pandemic began in the early 1980s. There is no vaccine or cure, although increasingly sophisticated drugs have helped patients to control it thus increasing their life expectancy.
The virus is difficult to fight because it attacks immune system cells and also mutates constantly, making it a moving target for drugs or the immune system.
It has been almost impossible to make a vaccine that will affect the virus. Last September, researchers reported their biggest success yet with a vaccine that appeared to slow the rate of infection by about 30 per cent in Thai volunteers, but one analysis claimed the results weren't statistically significant.
Researchers have been looking for parts of the virus that do not mutate so they can design vaccines that will protect against these constantly changing versions.
Dr Nabel's team found two of the antibodies in the blood of a patient infected with HIV who had not become ill despite the infection, using a new molecular device that they invented.
One of the antibodies partially mimics the way an immune cell called a CD4 T-cell attaches to a piece of the AIDS virus called gp120, the researchers said.
'The antibodies attach to a virtually unchanging part of the virus, and this explains why they can neutralize such an extraordinary range of HIV strains,' study co-author Dr John Mascola said.
In another experiment, the team managed to freeze one of the antibodies in the process of attaching to and neutralizing the virus. They were then able to study it by creating an atomic-level image in a process called x-ray crystallography.
The various breakthroughs have provided a renaissance in HIV research.
Dr Nabel said: 'I am more optimistic about an AIDS vaccine at this point in time than I have been probably in the last 10 years.
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